Key result
Loxoprofen induces severe anaphylaxis and fulminant DIC in a patient, resolving rapidly with targeted therapy.
Loxoprofen administration can rarely trigger severe anaphylaxis complicated by fulminant disseminated intravascular coagulation.
Urges vigilance for severe anaphylaxis and DIC with loxoprofen; extends NSAID adverse event spectrum but should not yet change practice.
A 66-year-old Japanese man received loxoprofen twice for pain in his right first toe. Systemic pruritus and flushing subsequently appeared, and his body movements became difficult with drowsy consciousness. He was admitted to the intensive care unit, where he was administered epinephrine, prednisolone, and d-chlorpheniramine maleate for hypotension, systemic pruritus, and flushing. Severe hypofibrinogenemia, APTT, PT-INR prolongation, and markedly increased FDP were observed. He was diagnosed with anaphylaxis and disseminated intravascular coagulation (DIC). After a transfusion of FFP and antithrombin concentrates, the coagulopathy rapidly improved. Subsequently, the patient was discharged without any bleeding or thrombotic episodes six days after admission.
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Takahashi et al. (2026) studied this question. Loxoprofen induced severe anaphylaxis and fulminant disseminated intravascular coagulation in a 66-year-old patient, which rapidly resolved after targeted medical therapy and transfusions.
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