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March 26, 2026Materials Today BioOpen Access

From Permeation Enhancer to Therapeutic Enabler: Advances, Applications, and Translational Perspectives in Hyaluronidase-Based Drug Delivery

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Authors

YSYuna SeoJSJiyoon SungJLJae-Young Lee

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Overview

This review discusses hyaluronidase-enhanced drug delivery mechanisms, applications in oncology, and formulation improvements.

Key Points

  • The aim is to explore advancements in using hyaluronidase for improving drug delivery systems, particularly for protein therapies.
  • Classified hyaluronidases based on biological sources and mechanisms.
  • Summarized clinical advancements of recombinant human hyaluronidase.
  • Discussed formulation stabilization techniques and injectability improvements.
  • Examined pharmacokinetic models for drug distribution and exposure.
  • Hyaluronidase significantly enhances the permeability of drugs by remodeling the extracellular matrix.
  • Formulation optimization improves enzyme stability and performance.
  • Incorporation of hyaluronidase in oncology aids immune-cell infiltration and overcomes tumor resistance.

Cite This Study

Seo et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc02fdc3bde44891763ahttps://doi.org/10.1016/j.mtbio.2026.103052
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