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November 1, 2025Journal of Cosmetic DermatologyOpen Access

Hyalase in Dermatology: Applications Beyond Filler Management

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Authors

SHSaba HasanzadehPFParisa FarokhGHGolsa Sadat Hosseini

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Overview

Review uncovers hyaluronidase's role in enhancing drug delivery and treating keloids, scleroderma, and fibrosis.

Key Points

  • To explore the diverse applications of hyaluronidase in dermatology beyond filler management.
  • Conducted a comprehensive review of hyaluronidase applications in medicine and dermatology using PubMed/MEDLINE, the Cochrane Library, and Embase.
  • Evaluated protocols for conditions treated with hyaluronidase.
  • Hyaluronidase improves tissue permeability and enhances drug delivery.
  • Beneficial for treating keloids, managing pain, and distributing chemotherapeutic agents within tumors.
  • Useful for reducing fibrosis in scleroderma and scleromyxedema.

Cite This Study

Hasanzadeh et al. (2025) studied this question.

synapsesocial.com/papers/6925435ec0ce034ddc3580a2https://doi.org/10.1111/jocd.70543
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Diverse Roles of Hyaluronidase: Revealing Its Biochemical, Preclinical, and Clinical Applications2025
  2. 2Topical Hyaluronidase: the Possibilities of Effective Use in Dermatology and Cosmetology2024
  3. 3From Permeation Enhancer to Therapeutic Enabler: Advances, Applications, and Translational Perspectives in Hyaluronidase-Based Drug Delivery2026 · 2 citations
  4. 4Hyaluronidase in Aesthetic Plastic Surgery: Clinical Uses, Safety, Ultrasound Guidance, And Current Controversies2026
  5. 5The clinical evidence and strategic use of hyaluronidase in spinal interventions2026