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March 26, 2026Environmental Toxicology and PharmacologyOpen Access

Short-term ecotoxicogenomic responses reveal early molecular mechanisms of Pyraclostrobin toxicity in honey bees

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Authors

JSJaine da Luz SchefferILIsabella Cristina de Castro LippiYLYan Souza Lima

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Overview

Ecotoxicogenomic analysis reveals early molecular changes due to pyraclostrobin in honey bees, indicating potential threats.

Key Points

  • This research aims to identify the molecular mechanisms underlying pyraclostrobin toxicity in honey bees.
  • Determined the oral lethal dose (LD 50) of pyraclostrobin in Africanized Apis mellifera.
  • Evaluated transcriptomic responses in forager bees after one and four-hour exposure to contaminated syrup.
  • Conducted RNA sequencing on head tissues to assess gene expression changes.
  • The LD 50 of pyraclostrobin was found to be 8.85 μg/bee.
  • After one hour, 432 genes showed differential expression, with 104 genes common to both lethal and sublethal doses.
  • Upregulated genes were linked to detoxification and immune pathways, indicating early stress responses.

Cite This Study

Scheffer et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc75fdc3bde448917aa7https://doi.org/10.1016/j.etap.2026.105004
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