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November 19, 2025Applied Biological ChemistryOpen Access

Head-specific transcriptomic profiles associated with chronic exposure to lambda-cyhalothrin and spinetoram during larval stage in honey bees (Apis mellifera)

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Authors

BVBala Murali Krishna VasamsettiHLHyunjun LeeKCKyongmi Chon

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Overview

Differential expression analysis shows distinct molecular pathways impacted by lambda-cyhalothrin and spinetoram in honey bees, implying risks for colony health.

Key Points

  • To investigate the molecular mechanisms of pesticide exposure during larval development in honey bees.
  • Examined transcriptomic alterations in adult honey bee heads after larval exposure to lambda-cyhalothrin and spinetoram.
  • Conducted differential expression analysis to identify differentially expressed genes.
  • Performed Gene Set Enrichment Analysis to assess molecular pathways affected by pesticide exposure.
  • Identified 6,166 differentially expressed genes in lambda-cyhalothrin treated heads, with a significant number upregulated and downregulated.
  • Revealed distinct transcriptomic signatures for each pesticide, impacting signaling and metabolic pathways in honey bees.
  • Validation through quantitative reverse transcription PCR showed strong concordance with RNA-seq results.

Cite This Study

Vasamsetti et al. (2025) studied this question.

synapsesocial.com/papers/6924fed8c0ce034ddc351119https://doi.org/10.1186/s13765-025-01060-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic Larval Exposure to Lambda-Cyhalothrin Alters Gene Expression in Both Larval and Adult Honey Bees (Apis mellifera)2025
  2. 2Assessment of Lambda-Cyhalothrin and Spinetoram Toxicity and Their Effects on the Activities of Antioxidant Enzymes and Acetylcholinesterase in Honey Bee (Apis mellifera) Larvae2024 · 32 citations
  3. 3Transcriptomic analysis of the honey bee (Apis mellifera) queen brain reveals that gene expression is affected by pesticide exposure during development2023 · 8 citations
  4. 4Short-term ecotoxicogenomic responses reveal early molecular mechanisms of Pyraclostrobin toxicity in honey bees2026 · 1 citations
  5. 5Sublethal λ-cyhalothrin disrupts sensory perception, learning, and memory, and induces oxidative stress in the honeybee, Apis mellifera L.2026