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April 27, 2023PLoS ONEOpen Access

Transcriptomic analysis of the honey bee (Apis mellifera) queen brain reveals that gene expression is affected by pesticide exposure during development

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Authors

MDMyra DickeyEWElizabeth M. WalshTSTonya F. Shepherd

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Overview

Experimental study reveals developmental pesticide exposure alters brain gene expression in honey bee queens, indicating potential sublethal impacts on colony health.

Key Points

  • To characterize how developmental exposure to wax-borne pesticides commonly found in commercial apiaries affects the honey bee queen brain transcriptome.
  • Reared developing queen larvae in wax treated with tau-fluvalinate plus coumaphos (FC), chlorpyrifos plus chlorothalonil (CC), amitraz alone (A), or pesticide-free control wax.
  • Allowed adult queens to mate naturally and harvested brain tissue from N=3 queens per group for RNA sequencing with three technical replicates per queen.
  • Identified 247 differentially expressed genes (DEGs) in the FC treatment group compared to controls using a log2 fold-change cutoff of 1.5.
  • Identified 244 DEGs in the CC treatment group and 668 DEGs in the amitraz group relative to pesticide-free controls.

Cite This Study

Dickey et al. (2023) studied this question.

synapsesocial.com/papers/6a952e046d8ecf100b25e1eehttps://doi.org/10.1371/journal.pone.0284929
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Also Consider

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  1. 1Immune pathways and defence mechanisms in honey bees <i>Apis mellifera</i>2006 · 1,047 citations
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  4. 4Global Transcriptomic Effects of Environmentally Relevant Concentrations of the Neonicotinoids Clothianidin, Imidacloprid, and Thiamethoxam in the Brain of Honey Bees (Apis mellifera)2018 · 107 citations