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March 24, 2026

Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence.

Carlos R. Montes-de-Oca-Saucedo SHEILA ADELA VILLA-CEDILLO Cristina Sarahi Ríos-Vazquez Eduardo A Álvarez-Tostado-Ojeda Mario Murguía-Pérez Eduardo Agustín-Godínez Ricardo Ruiz-Salazar Adolfo Soto-Domínguez Odila Saucedo-Cárdenas

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Key Points

The study aims to investigate the effects of caloric restriction on age-related changes in liver and kidney structures in mice.
Long-term caloric restriction was implemented in mice throughout aging.
Hepatic and renal histological assessments were conducted to evaluate tissue architecture and health.
Metabolic overload, fibrotic remodeling, and cellular senescence were analyzed alongside SIRT1 and p53 profiles.
Hepatic and renal structures showed preserved histoarchitecture with caloric restriction.
Caloric restriction reduced signs of fibrotic remodeling in both liver and kidneys.
SIRT1/acetyl-p53 levels were sustained, indicating lower p53 activation associated with caloric restriction.

Implication

Long-term caloric restriction preserves liver and kidney structure in aging mice, suggesting potential health benefits.

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Cite This Study

Montes-de-Oca-Saucedo et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc75fdc3bde448917bb9 https://doi.org/10.14670/hh-25-065

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