Endoscopic Management for Non-variceal Upper Gastrointestinal Bleeding: A Network Meta-analysis of Randomized Controlled Trials and Cost-Effectiveness Analyses of Two Healthcare Systems

Noppachai Siranart; Yanisa Chumpangern; Patavee Pajareya; Pannathorn Nakaphan; Tanattida Kassels; Watsapon Chuanchai; Sireenada Sattawatthamrong; Panisara Fangsaard; Peenaprapa Tangpradubkiat; Steven N. Steinway; Kittithat Tantitanawat; Sakkarin Chirapongsathorn

doi:10.14309/ajg.0000000000004000

March 24, 2026The American Journal of Gastroenterology

Endoscopic Management for Non-variceal Upper Gastrointestinal Bleeding: A Network Meta-analysis of Randomized Controlled Trials and Cost-Effectiveness Analyses of Two Healthcare Systems

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Key Points

The aim is to evaluate the effectiveness and cost-effectiveness of different endoscopic interventions for non-variceal upper gastrointestinal bleeding.
Conducted a network meta-analysis comparing OTSC, HP, and ST
Included randomized controlled trials and cost-effectiveness analyses
Assessed efficacy and cost-effectiveness in two healthcare systems
OTSC showed superior efficacy compared to HP and ST
OTSC was more cost-effective than both HP and ST
Recommended as first-line intervention for NVGIB based on findings

Implication

Network meta-analysis reveals OTSC is more effective and cost-effective than HP and ST for NVGIB.

Abstract

OTSC was superior to HP and ST in terms of efficacy and cost-effectiveness, favoring its use as a first-line endoscopic hemostasis intervention for NVGIB.

Discussion

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Cite This Study

Siranart et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccf7fdc3bde448918a8b https://doi.org/10.14309/ajg.0000000000004000

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Endoscopic Management for Non-variceal Upper Gastrointestinal Bleeding: A Network Meta-analysis of Randomized Controlled Trials and Cost-Effectiveness Analyses of Two Healthcare Systems

Key Points

Implication

Abstract

Discussion

Cite This Study

Endoscopic Management for Non-variceal Upper Gastrointestinal Bleeding: A Network Meta-analysis of Randomized Controlled Trials and Cost-Effectiveness Analyses of Two Healthcare Systems

Key Points

Implication

Abstract

Discussion

Cite This Study

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