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March 26, 2026Circulation Reports1 citationsOpen Access

Recurrence of Takotsubo Syndrome　― Incidence and Clinical Characteristics ―

YNYuki NishimuraJKJunya KomatsuHNHiroki Nakayama

Key Result

Takotsubo syndrome carries a substantial risk of recurrence, although the specific clinical factors associated with this recurrence remain uncertain.

Key Points

  • This research aims to explore the incidence and clinical characteristics associated with the recurrence of takotsubo syndrome.
  • Analyzed patient data on takotsubo syndrome
  • Examined factors contributing to recurrence
  • Evaluated clinical characteristics of cases
  • Noted a high incidence of recurrence in takotsubo syndrome cases
  • Identified several risk factors associated with recurrence
  • Described specific clinical characteristics of recurrent cases

Structured PICO

P
Population
Consecutive patients diagnosed with Takotsubo syndrome (TTS), median age 80 years, 80% female
O
Outcome
Incidence and predictors of TTS recurrencehard clinical

In very old patients with Takotsubo syndrome, the recurrence rate is 5.5%, and the absence of a definable trigger at the initial event is a strong independent predictor of recurrence.

Limitations

  • retrospective, single-center design
  • recurrence rate may have been underestimated as some patients were not followed continuously
  • relatively small number of patients with recurrence

Abstract

Background: Although takotsubo syndrome (TTS) carries a substantial risk of recurrence, the factors associated with recurrence remain uncertain.

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Cite This Study

Nishimura et al. (2026) studied this question. Takotsubo syndrome carries a substantial risk of recurrence, although the specific clinical factors associated with this recurrence remain uncertain.

synapsesocial.com/papers/69c4ccf7fdc3bde448918acbhttps://doi.org/10.1253/circrep.cr-25-0211
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of Recurrent Takotsubo Syndrome2024 · 4 citations
  2. 2Short-term recurrence of takotsubo syndrome with phenotypic variation: a case report2023 · 5 citations
  3. 3Takotsubo Syndrome Recurrence: A Trigger for Increased 30-Day Cardiovascular Mortality2025 · 6 citations
  4. 4Clinical and echocardiographic analysis of patients suffering from recurrent takotsubo cardiomyopathy.2016 · 29 citations
  5. 5Retrospective Diagnosis of Recurrent Takotsubo Syndrome Episodes in a 40-Year-Old Woman2026