What question did this study set out to answer?

To verify the efficacy of NexGard® PLUS against natural infestations of O. cynotis in dogs.

March 26, 2026

Field efficacy of a combination of afoxolaner, moxidectin and pyrantel pamoate against natural infestation with

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Authors

ETEric TielemansBoehringer Ingelheim (France)GSGeorgios SioutasAristotle University of Thessaloniki EPElias C. PapadopoulosAristotle University of Thessaloniki

Discussion

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Implication

A clinical efficacy study demonstrates significant treatment effects of NexGard® PLUS in dogs infested with Otodectes cynotis, highlighting its effectiveness.

Key Points

To verify the efficacy of NexGard® PLUS against natural infestations of O. cynotis in dogs.
Conducted a blinded, randomised, single-centre, negative controlled clinical efficacy study.
Allocated 24 dogs into three groups: untreated control, treated on Day 0, and treated on Days 0 and 29.
Performed otoscopic examinations on multiple days to evaluate clinical otodectic mange.
Collected ear canal flushings for O. cynotis counts on Day 56 to assess primary efficacy.
Treatment groups showed significant reductions in O. cynotis counts: 100% reduction for Day 0 and 99.7% for Days 0 and 29 (both p < 0.001).
Otoscopic examinations indicated treatment effects by Day 14, highly significant by Day 29.
The untreated control group had an average of 48.8 live mites by Day 56.

Cite This Study

Tielemans et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd25fdc3bde4489191b0 https://doi.org/10.1051/parasite/2026015/pdf

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Implication

A clinical efficacy study demonstrates significant treatment effects of NexGard® PLUS in dogs infested with Otodectes cynotis, highlighting its effectiveness.

Field efficacy of a combination of afoxolaner, moxidectin and pyrantel pamoate against natural infestation with

Discussion

Member takes

Implication

Key Points

Cite This Study

Field efficacy of a combination of afoxolaner, moxidectin and pyrantel pamoate against natural infestation with

Discussion

Member takes

Implication

Key Points

Cite This Study

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