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March 24, 2026Trends in Glycoscience and Glycotechnology

Regulatory Mechanisms of FUT8 Activity and Expression in Cells

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Key Points

The study aims to clarify the regulatory mechanisms of FUT8 enzyme activity and expression in cells.
Analyzed the function of the non-catalytic domains of FUT8, including SH3 and Stem regions.
Identified proteases SPP and SPPL3 involved in FUT8 secretion and cleavage.
Investigated the relationship between FUT8 activity and core fucosylation of substrate proteins.
FUT8 enzyme activity and stability are regulated by its non-catalytic domains.
SPP and SPPL3 play a critical role in the cleavage and secretion of FUT8.
Identified mechanisms provide new insights into the regulation of glycan modifications.

Implication

This research reveals the control of FUT8 enzyme activity in cells, suggesting implications for cancer diagnostics and treatment.

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Cite This Study

Seita Tomida (2026) studied this question.

synapsesocial.com/papers/69c4cd3efdc3bde4489195e5 https://doi.org/10.4052/tigg.2509.4j

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Activity of α1,6-fucosyltransferase (FUT8) is reduced by depletion of oligosaccharyltransferase subunits2025
2Advances in cancer research on FUT8 molecular mechanisms and clinical applicationsReview · 2025 · 8 citations
3Development of a FUT8 Inhibitor with Cellular Inhibitory Properties2024 · 1 citations
4Development of a FUT8 Inhibitor with Cellular Inhibitory Properties2024 · 9 citations
5FUT8-Dependent Core Fucosylation: Essential for Platelet Function and a Target in Thrombosispreclinical · 2026

More related papers

Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression2026
Identification of new fucosyltransferase-8 inhibitors: An integrated biochemical, biophysical, and computational approach2026
FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression2026

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