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March 26, 2026Psychophysiology

Multimodal Spatiotemporal Dynamics of Frontomedial Theta and BOLD Signal Reveal Functional Roles in Updating and Suppressing Aversive Memory During Fear Extinction

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Authors

AGArslan GabdulkhakovMSMatthias F. J. SperlPhilipps University of MarburgCMChristian J. Merz

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Implication

Investigates theta oscillations and BOLD signals during fear acquisition and extinction, suggesting implications for memory updating.

Key Points

  • The research aims to uncover the role of frontomedial theta oscillations in fear learning and extinction processes.
  • Employed simultaneous EEG and fMRI in fifty healthy individuals.
  • Used a one-day differential fear conditioning paradigm.
  • Analyzed frontomedial theta power across three trial segments.
  • Integrated theta measures into whole-brain fMRI analyses.
  • Significant increase in theta power was observed during fear acquisition training.
  • Distinct theta-BOLD co-activations detected in specific brain regions at different time segments.
  • Theta activity during extinction training correlated with BOLD signals in vmPFC.
  • Findings suggest theta oscillations contribute to memory updating during extinction learning.

Cite This Study

Gabdulkhakov et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd49fdc3bde448919604https://doi.org/10.1111/psyp.70281
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Context, learning, and extinction.2010 · 420 citations
  2. 2Amygdalar and Hippocampal Theta Rhythm Synchronization During Fear Memory Retrieval2003 · 743 citations
  3. 3The Importance of the Normality Assumption in Large Public Health Data Sets2002 · 1,811 citations
  4. 4Fear and safety learning in anxiety- and stress-related disorders: An updated meta-analysis2024 · 40 citations