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June 12, 2026Nature CommunicationsOpen Access

Adaptive shifts in amygdala–hippocampal theta coupling govern aversive learning and extinction

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Authors

SSSaurabh SonkusareQDQiong DingCWChristopher Weirich

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Overview

Randomized trial identifies frequency shifts in amygdala-hippocampal interactions during aversive learning, suggesting neural mechanisms for emotional memory regulation.

Key Points

  • This research aims to understand how amygdala-hippocampal interactions influence aversive learning and extinction processes.
  • Utilized intracranial EEG recordings from the amygdala and hippocampus over two days during a learning and extinction task.
  • Analyzed frequency-specific power changes in theta, gamma, and alpha bands during conditioning and extinction phases.
  • Investigated directional phase connectivity dynamics between amygdala and hippocampus.
  • Increased amygdala theta (3-8 Hz) and gamma (30-45 Hz) power during conditioning, decreased during extinction.
  • Hippocampal activity shifted from alpha and gamma to theta and gamma during extinction.
  • Amid phase connectivity, reversals were observed with amygdala dominance at 3-5 Hz and hippocampal dominance at 6-8 Hz, verified by computational modeling.

Cite This Study

Sonkusare et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba4d68101cf8926f03271https://doi.org/10.1038/s41467-026-73967-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adaptive shifts in amygdala–hippocampal theta coupling govern aversive learning and extinction2026
  2. 2Multimodal Spatiotemporal Dynamics of Frontomedial Theta and <scp>BOLD</scp> Signal Reveal Functional Roles in Updating and Suppressing Aversive Memory During Fear Extinction2026 · 1 citations
  3. 3Representational dynamics during extinction of fear memories in the human brain2025
  4. 4Human hippocampal reactivation of amygdala encoding-related gamma patterns during aversive memory retrieval2025
  5. 5Beta bursts mediate amygdala gating of hippocampal emotional encoding2025