Characterisation of the Novel HLA‐C*05:315 Allele by Sequencing‐Based Typing

Key Points

• The aim is to characterize the HLA-C*05:315 allele and understand its genetic variation compared to HLA-C*05:01:01:02.
• Utilized sequencing-based typing techniques
• Compared HLA-C*05:315 with HLA-C*05:01:01:02
• Focused on codon 304 in exon 5
• Identified a single nucleotide substitution in codon 304 of HLA-C*05:315
• Established genetic differences between HLA-C*05:315 and HLA-C*05:01:01:02