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The aim is to characterize the HLA-C*05:315 allele and understand its genetic variation compared to HLA-C*05:01:01:02.

March 26, 2026HLA

Characterisation of the Novel HLA‐C*05:315 Allele by Sequencing‐Based Typing

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The aim is to characterize the HLA-C*05:315 allele and understand its genetic variation compared to HLA-C*05:01:01:02.
Utilized sequencing-based typing techniques
Compared HLA-C*05:315 with HLA-C*05:01:01:02
Focused on codon 304 in exon 5
Identified a single nucleotide substitution in codon 304 of HLA-C*05:315
Established genetic differences between HLA-C*05:315 and HLA-C*05:01:01:02

Sequencing analysis uncovers HLA-C*05:315 differences in genetic coding, suggesting diverse immune responses.

HLA‐C*05:315 differs from HLA‐C*05:01:01:02 by one nucleotide substitution in codon 304 in exon 5.

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Blandin et al. (2026) studied this question.

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Sequencing analysis uncovers HLA-C*05:315 differences in genetic coding, suggesting diverse immune responses.

HLA‐C*05:315 differs from HLA‐C*05:01:01:02 by one nucleotide substitution in codon 304 in exon 5.