What does this research mean for the field?

The novel HLA-C*02:02:81 allele differs from the established HLA-C*02:02:02:01 allele by a single nucleotide substitution in codon 294 of exon 5. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to characterize the novel HLA-C*02:02:81 allele through molecular typing methods.

June 20, 2026HLA

Characterisation of the Novel HLA‐C*02:02:81 Allele by Sequencing‐Based Typing

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The aim is to characterize the novel HLA-C*02:02:81 allele through molecular typing methods.
Used sequencing-based typing to identify genetic differences
Focused on nucleotide sequence variations in exon 5
HLA-C*02:02:81 differs from HLA-C*02:02:02:01 by one nucleotide substitution
The change occurs specifically at codon 294

Implication

Novel allele HLA-C*02:02:81 is distinguished by a single nucleotide change in a specific codon.

Abstract

HLA-C*02:02:81 differs from HLA-C*02:02:02:01 by one nucleotide substitution in codon 294 in exon 5.

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Cite This Study

Humeau et al. (2026) studied this question.

synapsesocial.com/papers/6a36300ddb0793dc1a53753d https://doi.org/10.1111/tan.70812

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Implication

Novel allele HLA-C*02:02:81 is distinguished by a single nucleotide change in a specific codon.

Abstract

HLA-C*02:02:81 differs from HLA-C*02:02:02:01 by one nucleotide substitution in codon 294 in exon 5.

Characterisation of the Novel HLA‐C*02:02:81 Allele by Sequencing‐Based Typing

Key Points

Implication

Abstract

Discussion

Cite This Study

Characterisation of the Novel HLA‐C*02:02:81 Allele by Sequencing‐Based Typing

Key Points

Implication

Abstract

Discussion

Cite This Study

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