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March 26, 2026Current Opinion in Genetics & DevelopmentOpen Access

At the tip of regeneration

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Authors

CDCamille E. DumasLCLauren ConnollyMSMekayla A. Storer

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Overview

Review highlights cellular and systemic influences on digit tip regeneration in mammals, suggesting integrated repair processes.

Key Points

  • To explore the cellular and systemic factors that influence mammalian digit tip regeneration.
  • Review of existing literature on mammalian regeneration processes.
  • Analysis of local tissue environments and their role in blastema formation.
  • Examination of systemic signals, including immune and neuroendocrine factors.
  • Identified key roles of the nail organ and fibroblast heterogeneity in regeneration.
  • Demonstrated how inflammatory dynamics affect tissue repair.
  • Highlighted the interaction between local cues and systemic physiological regulation.

Cite This Study

Dumas et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd5afdc3bde4489198e7https://doi.org/10.1016/j.gde.2026.102462
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