What question did this study set out to answer?

The aim is to explore the histological transformation of marginal zone lymphoma associated with Epstein–Barr virus.

March 26, 2026Virchows ArchivOpen Access

EBV-associated histological transformation of marginal zone lymphomas: two case reports and a literature review

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Case reports illustrate EBV-associated transformation outcomes in marginal zone lymphoma, suggesting variable prognoses.

The aim is to explore the histological transformation of marginal zone lymphoma associated with Epstein–Barr virus.
Reported two cases of EBV-associated histological transformation in marginal zone lymphoma.
Analyzed clinicopathological features and treatments of both cases.
Conducted polymerase chain reaction-based clonality analysis and target panel sequencing.
Both cases transformed into EBV-positive diffuse large B-cell lymphoma.
EBV-positive cells were found in only one of the initial marginal zone lymphomas.
Patient prognoses varied significantly after treatment, with one patient in remission for 14 months.

Naito et al. (2026) studied this question.

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