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August 7, 2026Current OncologyOpen Access

Clinical Characteristics and Prognostic Analysis of EBV-Positive HIV-Associated Diffuse Large B-Cell Lymphoma in China: A Retrospective Single-Center Study

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Authors

LFLizhi FengGuangzhou Institute of DermatologyHHHaolan HeGuangzhou Institute of DermatologyHZHan ZhaoGuangzhou Institute of Dermatology

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Implication

Retrospective analysis reveals aggressive features and poorer survival for EBV-positive DLBCL in HIV-infected individuals, suggesting enhanced risk stratification.

Key Points

  • This study aims to analyze the clinical characteristics and prognostic factors of EBV-positive HIV-associated DLBCL cases.
  • Retrospective analysis of 103 cases (32 EBV-positive, 71 EBV-negative) at a single center.
  • Clinical features, plasma EBV DNA levels, and overall survival were examined using Kaplan–Meier and Cox regression models.
  • Immunological parameters and histological subtypes were assessed.
  • EBV-positive patients exhibited higher circulating EBV loads and lower CD4+ T-cell counts compared to EBV-negative cases.
  • Overall survival did not significantly differ across the cohort but was shorter in EBV-positive patients with high International Prognostic Index scores or CD4+ counts ≥ 50 cells/μL.
  • Plasma EBV DNA levels were associated with poorer survival outcomes, indicating its potential as a prognostic biomarker.

Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/6a758be1847ab6d26c01f73chttps://doi.org/10.3390/curroncol33080466
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