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December 8, 2025BloodOpen Access

Distinct genomic landscape & response dynamics of HIV-associated lymphomas identified by integrated noninvasive host and virome profiling

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Authors

SSShuyu ShiAGAndrea GarofaloTSTakeshi Sugio

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Overview

Integrated profiling reveals HIV impact on tumor dynamics and disease outcomes in lymphoma patients, indicating treatment targets.

Key Points

  • To explore the distinct genomic and viral characteristics of HIV-associated lymphomas compared to non-HIV counterparts.
  • Profiled 305 blood samples from 122 patients, including HIV+ and HIV- lymphomas.
  • Identified viral dynamics using VirCAPP-Seq and CAPP-Seq targeting specific genes and viral species.
  • Examined correlations between ctDNA, cfEBV levels, and clinical outcomes.
  • HIV+ lymphomas had unique viral profiles linked to poorer outcomes.
  • Elevated levels of Epstein-Barr Virus correlated with lymphomas in HIV+ patients.
  • Minimal residual disease presence predicted disease-free survival in HIV+ lymphoma patients.

Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dae0https://doi.org/10.1182/blood-2025-5320
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 786: Genomic distinctions of HIV- and EBV-associated DLBCL in a diverse African cohort2024
  2. 2Applying Computational Pipelines to Transcriptomic Data from Virally Associated Lymphomas in Malawi2026
  3. 3Clinical Characteristics and Prognostic Analysis of EBV-Positive HIV-Associated Diffuse Large B-Cell Lymphoma in China: A Retrospective Single-Center Study2026
  4. 4HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins2025 · 1 citations
  5. 5Characterization of the genomic landscape of HIV-associated lymphoma reveals heterogeneity across histological subtypes2024 · 5 citations