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October 18, 2025Open Access

HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins

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Authors

ACAmy ChadburnMAMontserrat Aguilar-HernándezJDJoanne Dai

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Overview

Genome-wide spatial transcriptomic analyses elucidate tumor microenvironment differences in HIV-NHL, suggesting tailored therapies based on EBV status.

Key Points

  • EBV+ non-hodgkin lymphoma tumors exhibited unique metabolic signatures and limited immune infiltration.
  • Expression levels of ferroportin indicated an immunosuppressive environment in EBV+ tumors compared to EBV- tumors.
  • The study applied genome-wide spatial transcriptomic analyses to characterize tumors based on EBV status and cellular origins.
  • Findings may guide NHL therapies tailored to EBV status, addressing critical gaps in understanding tumor biology.

Cite This Study

Chadburn et al. (2025) studied this question.

synapsesocial.com/papers/68f3793258f37cefb60d33b4https://doi.org/10.1101/2025.10.15.682084
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin Lymphoma.2024 · 5 citations
  2. 2Epstein-Barr Virus and immune status imprint the immunogenomics of non-Hodgkin lymphomas occurring in immune-suppressed environments2024 · 5 citations
  3. 3Distinct genomic landscape & response dynamics of HIV-associated lymphomas identified by integrated noninvasive host and virome profiling2025
  4. 4Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment2024 · 3 citations
  5. 5Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment2026