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March 7, 2024Open Access

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

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Authors

YYYao Yu YeoHQHuaying QiuYBYunhao Bai

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Overview

Multiplexed imaging reveals EBV's role in immune dysfunction and tumor dynamics in Hodgkin lymphoma.

Key Points

  • EBV-positive cHL shows increased T-cell dysfunction and a distinct immune signature, affecting tumor dynamics.
  • Key differences include the predominance of memory CD8 T cells and their dysfunction near HRS cells.
  • Spatial multi-omics analysis revealed contrasting transcriptomic signatures in EBV-positive vs negative cases across 46 samples during the study period.  |  MIBI was utilized to analyze the TME at high detail for better insights into immune interactions.

Cite This Study

Yeo et al. (2024) studied this question.

synapsesocial.com/papers/68e75556b6db6435876ccca4https://doi.org/10.1101/2024.03.05.583586
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment2026
  2. 2Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024 · 13 citations
  3. 3Data from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024
  4. 4HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin Lymphoma.2024 · 5 citations
  5. 5The Hodgkin Lymphoma Microenvironment: Insights from Spatial Transcriptomics2026