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December 8, 2025Blood

Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.

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Authors

TLTanja LazicRVRiccardo ValliETErica Travaglino

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Overview

Morphology-guided profiling shows immune escape mechanisms impact progression-free survival in classical Hodgkin lymphoma patients.

Key Points

  • To explore the interplay of Hodgkin Reed-Sternberg cells and the tumor microenvironment in classical Hodgkin lymphoma.
  • Retrospective analysis of 155 untreated classical Hodgkin lymphoma patients, classified by relapse status.
  • Morphology-guided spatial transcriptomics assessed transcriptional profiles in lymph node resections.
  • Cox regression analysis identified genes correlated with progression-free survival.
  • Hodgkin Reed-Sternberg cells showed significant differences between relapsed/refractory and non-relapsed classical Hodgkin lymphoma.
  • The tumor microenvironment in relapsed cases exhibited a strong immunosuppressed phenotype.
  • A non-tumoral B-cell gene signature correlated with improved progression-free survival.

Cite This Study

Lazic et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db1ehttps://doi.org/10.1182/blood-2025-5315
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