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December 8, 2025BloodOpen Access

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response

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Authors

MTMatthew TeaterJBJoshua BrodyAKAlexandra E. Kovach

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Overview

Transcriptome analysis reveals NK cell evasion and unfolded protein response pathways in Hodgkin lymphoma, suggesting immune escape mechanisms.

Key Points

  • The research aims to identify distinct molecular features of Hodgkin lymphoma and mechanisms of immune evasion.
  • Flow cytometric cell sorting to isolate Hodgkin and Reed-Sternberg cells
  • Low-input RNA sequencing to perform transcriptome analysis
  • Gene Set Enrichment Analysis to explore upregulated pathways
  • Immunohistochemistry to assess PDIA6 expression in tumors.
  • Revealed unique transcriptome features in Hodgkin lymphoma cells
  • Identified the unfolded protein response as upregulated in HRS cells
  • Confirmed downregulation of NK cell activating receptors
  • Showed reduced proportions of NK cells in Hodgkin lymphoma tumors.

Cite This Study

Teater et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e229https://doi.org/10.1182/blood-2025-3538
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response2026
  2. 2Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  3. 3Efferocytosis and M2 Macrophage Polarization Gene Expression Correlates With Relapsed and Refractory Classical Hodgkin Lymphoma Patients: A Multi‐Omic Analysis2025
  4. 4Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  5. 5Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024 · 13 citations