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September 23, 2025Hematological Oncology

Efferocytosis and M2 Macrophage Polarization Gene Expression Correlates With Relapsed and Refractory Classical Hodgkin Lymphoma Patients: A Multi‐Omic Analysis

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Authors

JBJuan Quarroz BraghiniMLMaría Cecilia Cabral LorenzoLKLaura Kornblihtt

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Overview

Multi-Omic analysis reveals efferocytosis and M2 macrophage roles in treatment failure among cHL patients.

Key Points

  • High expression of efferocytosis and M2 macrophage genes correlates with poor treatment response in cHL patients.
  • The study found that M2 macrophage proportions were significantly higher in patients who relapsed or did not respond to treatment.
  • By combining gene expression profiles and cell type proportions, researchers predicted treatment outcomes with high accuracy.
  • Identifying HRS cells using a 37-gene signature allows for better understanding of immune interactions affecting prognosis.

Cite This Study

Braghini et al. (2025) studied this question.

synapsesocial.com/papers/68d4739d31b076d99fa6bbd9https://doi.org/10.1002/hon.70135
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  2. 2Multiplex spatial analysis reveals increased CD137 expression and m-MDSC neighboring tumor cells in refractory classical Hodgkin Lymphoma2024 · 6 citations
  3. 3Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  4. 4Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024 · 13 citations
  5. 5Single‐cell RNA sequencing of pediatric Hodgkin lymphoma to study the inhibition of T cell subtypes2024 · 9 citations