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April 24, 2026Blood Cancer JournalOpen Access

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response

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Authors

MRMikhail RoshalIKIsabella Y. KongWDWikum Dinalankara

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Overview

Transcriptome analysis identifies immune evasion and UPR activation in Hodgkin lymphoma, suggesting novel treatment insights.

Key Points

  • This study aims to understand the transcriptional differences between Hodgkin lymphoma and primary mediastinal B cell lymphoma.
  • Performed flow cytometric cell sorting and low-input RNA sequencing of Hodgkin and Reed-Sternberg cells.
  • Compared findings with RNA sequencing data from primary mediastinal B cell lymphoma cases.
  • Hodgkin and Reed-Sternberg cells displayed robust unfolded protein response activation.
  • These cells showed significant immune evasion, including loss of natural killer cell recognition.
  • Notable differences in B cell identity were observed when compared to primary mediastinal B cell lymphoma.

Cite This Study

Roshal et al. (2026) studied this question.

synapsesocial.com/papers/69eb0bfa553a5433e34b56d7https://doi.org/10.1038/s41408-026-01502-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  2. 2Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  3. 3Hodgkin Reed-Sternberg Cells of Classic Hodgkin Lymphoma: Morphology, Phenotype, Genotype, and Cell of Origin2026
  4. 4Disordered differentiation and cellular senescence in pediatric Hodgkin Reed-Sternberg cells2026 · 1 citations
  5. 5Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024 · 13 citations