August 7, 2025Open Access

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Stenberg cells reveals escape from NK cell recognition and an unfolded protein response

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Core finding indicates HRS cells escape recognition by NK cells, suggesting immune evasion strategies.
Comprehensive transcriptome data reveals abortive plasma cell differentiation in HRS cells.
Methods included flow cytometric cell sorting and RNA sequencing from 18 primary Hodgkin lymphoma tumors.
Findings may provide insights into unique characteristics of Hodgkin lymphoma and guide therapeutic approaches.

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Transcriptome sequencing uncovers NK cell evasion in Hodgkin lymphoma, highlighting unique differentiation processes in HRS cells.

Roshal et al. (2025) studied this question.

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