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September 3, 2024

Data from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma

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Authors

MPMaryam PourmalekiMemorial Sloan Kettering Cancer CenterCJCaitlin J. JonesMemorial Sloan Kettering Cancer CenterSMSabrina D. MellinghoffBoston University

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Overview

Multiplexed analysis identifies immune-inflamed neighborhoods in classic Hodgkin lymphoma, suggesting immune escape mechanisms.

Key Points

  • Immune-inflamed neighborhoods contain MHC-I expressing Hodgkin Reed–Sternberg cells, CD8+ T cells, and macrophages, indicating a complex interaction.
  • In a study of 36 tumors, distinct spatial clustering and immune checkpoints like PD1 and VISTA were observed in Hodgkin Reed–Sternberg cell neighborhoods.
  • Assessment using spatially resolved multiplexed protein imaging and transcriptomic sequencing revealed gene expression patterns in 23.6 million cells from tumors.  This work highlights the role of immune landscapes in Hodgkin lymphoma, indicating potential immune escape, especially in EBV-negative tumors.

Cite This Study

Pourmaleki et al. (2024) studied this question.

synapsesocial.com/papers/68e598e8b6db6435875339cchttps://doi.org/10.1158/1078-0432.c.7429482.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024 · 13 citations
  2. 2Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  3. 3Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment2024 · 3 citations
  4. 4Hodgkin Reed-Sternberg Cells of Classic Hodgkin Lymphoma: Morphology, Phenotype, Genotype, and Cell of Origin2026
  5. 5Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment2026