Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Multimodal discovery of distinct tumor ecosystems for classic Hodgkin lymphoma

View Full Paper
Ask AI
Bookmark
Share

Authors

TFTimothy FlerlageSYSheren YounesOSOscar Silva

Discussion

Loading...

Member takes

Overview

Multimodal characterization reveals distinct tumor ecosystems in classic Hodgkin lymphoma, suggesting links to poorer outcomes with specific cell types.

Key Points

  • This research aims to characterize the tumor ecosystem in classic Hodgkin lymphoma using a multimodal approach.
  • Utilized 198 cHL cases from international cohorts for analysis.
  • Employed single cell RNA-seq to profile cell types in tumor samples.
  • Developed a cHL-specific signature matrix for RNA-seq analysis.
  • Applied a machine-learning model (EcoTyper) for ecosystem identification.
  • Validated findings with external datasets, including spatial transcriptomics.
  • Identified 16 cell phenotypes, including dendritic cells and natural killer cells.
  • Discovered two Hodgkin lymphoma ecotypes (HLE1 and HLE2) with distinct characteristics.
  • HLE2 showed worse freedom from progression, linked to specific cell types and gene expressions.

Cite This Study

Flerlage et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d76dhttps://doi.org/10.1182/blood-2025-1783
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  2. 2Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024 · 13 citations
  3. 3Data from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024
  4. 4Abstract IA002: Hodgkin lymphoma tumor microenvironment2026
  5. 5Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment2024 · 3 citations