Localized catalytic hairpin assembly-based DNA tetrahedral sensor for sensitive and rapid miRNA detection in living cells

Chunhui Zhao; Shenzhi Lai; Jiao He; Yuexiang Sun; Haoxiao Wang; Feng Chen; Chunyan Chen; Hang Gong; Changqun Cai

doi:10.1039/d6nj00672h

January 1, 2026New Journal of Chemistry

Localized catalytic hairpin assembly-based DNA tetrahedral sensor for sensitive and rapid miRNA detection in living cells

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to develop a fast and sensitive sensor for detecting miRNA using catalytic hairpin assembly.
Utilized catalytic hairpin assembly for signal amplification.
Designed a DNA tetrahedral structure for enhanced detection.
Conducted experiments in living cells to assess responsiveness.
Achieved rapid detection of miRNA in real-time.
Demonstrated high sensitivity to low-concentration targets.
Showed that the sensor works effectively in living cell environments.

Implication

Localized catalytic hairpin assembly detects miRNA in living cells, indicating potential for rapid diagnostics.

Abstract

Catalytic hairpin assembly (CHA) signal amplification strategies have been employed for the detection of lowconcentration targets, but it requires several hours of reaction time, which poses a challenge for real-time...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd8dfdc3bde44891a089 https://doi.org/10.1039/d6nj00672h

View Full Paper

Ask AI

Bookmark

Share

Localized catalytic hairpin assembly-based DNA tetrahedral sensor for sensitive and rapid miRNA detection in living cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Localized catalytic hairpin assembly-based DNA tetrahedral sensor for sensitive and rapid miRNA detection in living cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading