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January 1, 2025Nanoscale AdvancesOpen Access

A catalytic hairpin amplification platform triggered by near-infrared light and logic assembly for sensitive detection of microRNAs

Ruiqi Chen Bin Qiu Chen Chen Mingyuan Chen

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Key Points

This research focuses on developing a biosensor for the sensitive detection of microRNAs using near-infrared light.
Developed a NIR-active catalytic hairpin amplification (CHA) platform
Utilized logic assembly for improved sensitivity
Focus on quantifying miRNA-21 as a target molecule
Detection method shows enhanced sensitivity for microRNA quantification
Demonstrated effectiveness of the NIR-activated biosensor for miRNA-21 detection

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Implication

The NIR-triggered detection shows improved sensitivity for quantifying microRNA-21, indicating effective biosensor design.

Abstract

An NIR-active CHA biosensor for the quantification of miRNA-21.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a843 https://doi.org/10.1039/d5na00775e

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