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March 26, 2026Cancer MedicineOpen Access

Qualitative Study of Breast Cancer and Lymphoma Patients Participating in a Physical Activity Intervention: The Case for Tailored Physical Activity

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Why the study?

Exercise mitigates chemotherapy-related cardiotoxicity, but implementing exercise interventions during chemotherapy is challenging, and understanding patient perspectives can optimize future interventions.

What are the patient perspectives, barriers, and facilitators regarding participation in a tailored physical activity intervention during cardiotoxic chemotherapy?

Design

Qualitative semi-structured interview study

Key result

Tailored physical activity interventions and positive staff relationships enhance exercise adherence among breast cancer and lymphoma patients receiving cardiotoxic chemotherapy.

Authors

BLBrianna N. LeitzelarJCJuliana V. CostaAAAylin A. Aguilar

Discussion

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Overview

May warrant emphasis on tailored support and positive staff relationships; extends qualitative data on exercise adherence during cardiotoxic chemotherapy.

Key Points

  • This study aims to understand patient experiences to improve adherence in a tailored physical activity program for cancer patients undergoing chemotherapy.
  • Conducted semi-structured interviews with eighteen breast cancer and lymphoma patients.
  • Interviews focused on enrollment reasons, study experiences, and barriers to adherence.
  • Identified themes through an integrative synthesis of qualitative data.
  • Participants averaged 53 years old, with 50% being female and 83% identifying as White.
  • Main reasons for enrollment included altruism and provider recommendations.
  • Intrinsic motivation and positive experiences contributed to study completion.
  • Barriers to adherence were identified as symptom burden and lack of motivation.

Structured PICO

What are the patient perspectives, barriers, and facilitators regarding participation in a tailored physical activity intervention during cardiotoxic chemotherapy?

P
Population
18 breast cancer and lymphoma patients receiving potentially cardiotoxic chemotherapy, mean age 53 (SD=15), 50% female, 83% White, 61% non-Hodgkin Lymphoma.
I
Intervention
Tailored physical activity (PA) intervention
O
Outcome
Patient perspectives on reasons for enrollment or dropout, perceptions of study personnel, experiences within the study interventions, and barriers to intervention adherencepatient reported

Provider recommendation, altruism, and tailored interventions are key facilitators for implementing exercise programs to mitigate cardiotoxicity in cancer patients.

Cite This Study

Leitzelar et al. (2026) studied this question. Tailored physical activity interventions and positive staff relationships enhance exercise adherence among breast cancer and lymphoma patients receiving cardiotoxic chemotherapy.

synapsesocial.com/papers/69c4cda5fdc3bde44891a465https://doi.org/10.1002/cam4.71747
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