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March 26, 2026Ecotoxicology and Environmental Safety2 citationsOpen Access

Urban Heat Island Exposure and Mortality Risk Associated with Metabolomic Profiles

Associations of urban heat island and its metabolomic profiles with all-cause and cause-specific mortality in middle-aged and older adults

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Authors

JQJ. F. QiuHZHao ZhengJGJ Gu

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Overview

This prospective cohort study finds that urban heat island exposure increases mortality risk, indicating a need for climate resilience efforts.

Key Points

  • To investigate the link between urban heat island exposure and mortality while identifying metabolic pathways involved in these relationships.
  • Prospective cohort study using data from the UK Biobank (2006-2010)
  • Used satellite-derived land surface temperature data to estimate UHI exposure
  • Cox proportional hazards models assessed UHI and mortality associations
  • Elastic net regression identified metabolites related to UHI exposure
  • Mediation analyses quantified contributions of metabolites to mortality risk.
  • Long-term UHI exposure linked to an increased risk of all-cause mortality (HR: 1.05)
  • Strongest associations for endocrine (HR: 1.08) and respiratory diseases (HR: 1.08)
  • Glucose identified as the strongest mediator, explaining 31.7% of UHI effect on mortality
  • Interaction analyses showed that metabolite levels modify UHI-mortality associations.

Cite This Study

Qiu et al. (2026) studied this question.

synapsesocial.com/papers/69c4cda5fdc3bde44891a57chttps://doi.org/10.1016/j.ecoenv.2026.120062
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