What question did this study set out to answer?

To explore the diagnosis and treatment of paraneoplastic myositis associated with large B-cell lymphoma.

1457: Paraneoplastic Myositis From Large B-Cell Lymphoma: A Rare and Elusive Cause of Profound Weakness

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To explore the diagnosis and treatment of paraneoplastic myositis associated with large B-cell lymphoma.
Detailed clinical evaluation of a 59-year-old man with prior melanoma and new-onset muscle weakness.
Diagnostic imaging including MRI, PET scan, and laboratory tests for inflammatory markers and autoantibodies.
Therapeutic interventions including antibiotics, steroids, plasma exchange, and eventual surgery for suspected malignancy.
Identification of diffuse large B-cell lymphoma as the underlying cause of myositis.
Improvement in muscle strength after initiation of R-CHP chemotherapy.
Patient requiring extensive management including tracheostomy and feeding tube during treatment.

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Case report demonstrates paraneoplastic myositis linked to lymphoma causing profound weakness, indicating diagnostic challenges.

Biondi et al. (2026) studied this question.

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