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This case aims to present paraneoplastic myelopathy as an unusual first sign of relapsed ovarian cancer.

November 1, 2025Neuro-Oncology

NCMP-27. 73 year-old female with paraneoplastic myelopathy and ovarian cancer relapse

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This case aims to present paraneoplastic myelopathy as an unusual first sign of relapsed ovarian cancer.
Descriptive case report of a 73-year-old female with a history of ovarian cancer.
MRI imaging to assess spinal cord abnormalities.
CSF analysis and EMG to evaluate neurological function and disease state.
Treatment included IV methylprednisolone, PLEX, and chemotherapy.
Patient exhibited significant lower extremity weakness and paresthesias associated with myelopathy.
MRI indicated symmetric enhancement of spinocerebellar tracts in the lateral cord.
Biopsy confirmed recurrence of high-grade ovarian carcinoma, correlating with neurological symptoms.

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Case illustrates paraneoplastic myelopathy and ovarian cancer recurrence, highlighting the need for timely cancer-specific therapy.

Merrill et al. (2025) studied this question.

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