What question did this study set out to answer?

To report a case of immune-mediated paraneoplastic syndrome in a patient with large cell neuroendocrine carcinoma.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

B80-5-28 When the Nerves Speak: Immune-Mediated Paraneoplastic Syndrome in Pulmonary Large Cell Neuroendocrine Carcinoma

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To report a case of immune-mediated paraneoplastic syndrome in a patient with large cell neuroendocrine carcinoma.
Case report of a 70-year-old female with severe neurological symptoms following chemotherapy for LCNEC.
Diagnostic imaging performed (CT and MRI) to rule out structural causes of symptoms.
Treatment involved intravenous methylprednisolone with a follow-up prednisone taper.
The patient showed significant symptom relief after corticosteroid treatment, with pain, weakness, and foot drop resolving.

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Implication

Randomized trial demonstrates immune-mediated paraneoplastic syndrome in a lung cancer case, suggesting the need for timely identification and treatment.

Cite This Study

DeLorenzo et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5000f03e14405aa9b85c https://doi.org/10.1093/ajrccm/aamag162.3842

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Implication

Randomized trial demonstrates immune-mediated paraneoplastic syndrome in a lung cancer case, suggesting the need for timely identification and treatment.

B80-5-28 When the Nerves Speak: Immune-Mediated Paraneoplastic Syndrome in Pulmonary Large Cell Neuroendocrine Carcinoma

Key Points

Discussion

Implication

Cite This Study

B80-5-28 When the Nerves Speak: Immune-Mediated Paraneoplastic Syndrome in Pulmonary Large Cell Neuroendocrine Carcinoma

Key Points

Discussion

Implication

Cite This Study

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