What question did this study set out to answer?

To discover and synthesize two new marine oxazole derivatives that may have anticancer properties.

March 26, 2026

Isolation and First Total Synthesis of PM100618 and PM110049, Two Structurally Distinct Marine-Derived Anticancer Oxazole Derivatives

Key Points

To discover and synthesize two new marine oxazole derivatives that may have anticancer properties.
Isolated oxazole derivatives from the sponge Rhabdastrella rowi
Conducted structural elucidation of compounds PM100618 and PM110049
Achieved total synthesis of both compounds in 21-22 steps
Both PM100618 and PM110049 show potent cytotoxic activity at nanomolar concentrations
The synthesis was efficiently conducted using a convergent approach
The synthetic route enables further pharmacological evaluation of these compounds.

Abstract

We report the discovery, structural elucidation, and first total synthesis of two unprecedented marine oxazole derivatives, PM100618 and PM110049, isolated from the Papua New Guinean sponge Rhabdastrella rowi. Both compounds exhibit potent in vitro cytotoxic activity at nanomolar concentrations. A highly convergent and efficient total synthesis of PM100618 and PM110049 was achieved in 22 and 21 steps, respectively (longest linear sequence: 15 steps) through the coupling of two complex fragments. This synthetic route provides ready access to these scarce natural products, enabling advanced pharmacological evaluation and mechanistic studies of this new class of marine-derived anticancer agents.

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