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The research aims to develop a method to prevent hemorrhagic transformation after tPA treatment in stroke patients.

March 27, 2026Nature CommunicationsOpen Access

Polymersomes preventing brain infiltration of CD177+ neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis

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Demonstrates a new nanomedicine strategy to reduce hemorrhagic transformation in stroke patients during tPA treatment, suggesting improved safety.

The research aims to develop a method to prevent hemorrhagic transformation after tPA treatment in stroke patients.
Developed ROS-triggered polymersomes targeting fibrin with conjugated CREKA peptide for tPA encapsulation
Loaded recombinant CD177 protein into CP polymersomes for administration before thrombolysis
Utilized in vitro models to analyze the migration of CD177+ neutrophils and the formation of neutrophil extracellular traps
CP@rCD177 successfully reduced migration of CD177+ neutrophils into the brain
Prevented neutrophil extracellular traps formation, reducing microglial inflammation
Improved prognosis of hemorrhagic transformation after thrombolysis treatment

Wang et al. (2026) studied this question.

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Demonstrates a new nanomedicine strategy to reduce hemorrhagic transformation in stroke patients during tPA treatment, suggesting improved safety.