Rapid Catalyst-Free Synthesis of α-Selenomethyl Ketones from Sulfoxonium Ylides and Selenols †

Xuyang Gong; Huaiyu Huang; Taiwen Li; Qichen Liu; Xiaoqiong Fu; Haifeng Wang; Hao Zhoud; Shuangxi Gu

doi:10.1039/d6ob00428h

January 1, 2025Organic & Biomolecular Chemistry

Rapid Catalyst-Free Synthesis of α-Selenomethyl Ketones from Sulfoxonium Ylides and Selenols †

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Key Points

To develop a fast and efficient method for synthesizing α-arylselenomethyl ketones without catalysts.
Direct coupling of sulfoxonium ylides with benzeneselenol
Metal-free synthesis
Conducted under mild reaction conditions
Achieved synthesis of α-arylselenomethyl ketones rapidly
Exhibited high functional group tolerance
No catalyst required for the reaction

Implication

This method demonstrates a rapid synthesis of α-arylselenomethyl ketones, indicating a new approach to synthesis without catalysts.

Abstract

A rapid and catalyst-free synthesis of α-arylselenomethyl ketones has been developed via the direct coupling of sulfoxonium ylides with benzeneselenol. This metal-free protocol operates under mild conditions, exhibits excellent functional...

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Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/69c61fd715a0a509bde18396 https://doi.org/10.1039/d6ob00428h

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Rapid Catalyst-Free Synthesis of α-Selenomethyl Ketones from Sulfoxonium Ylides and Selenols †

Key Points

Implication

Abstract

Discussion

Cite This Study

Rapid Catalyst-Free Synthesis of α-Selenomethyl Ketones from Sulfoxonium Ylides and Selenols †

Key Points

Implication

Abstract

Discussion

Cite This Study

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