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This research aims to analyze the phytochemical composition and explore the pharmacological effects of sweet pomegranate fruit peels.

Phytochemical profiling and biological activity assessment of aqueous extract from sweet pomegranate (Punica granatum L.) fruit peels collected in the El Oued region, Algeria

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Characterizes phytochemicals and assesses antioxidant and anti-inflammatory effects in rats, indicating therapeutic potential.

This research aims to analyze the phytochemical composition and explore the pharmacological effects of sweet pomegranate fruit peels.
Conducted aqueous extraction of fruit peels using maceration.
Characterized phytochemicals using various assays for polyphenols, flavonoids, and tannins.
Assessed antioxidant activity through DPPH, FRAP, and ß-carotene tests.
Evaluated antibacterial effects using agar diffusion disc method.
Performed in vivo anti-inflammatory tests on Wistar albino rats.
Extract contained high levels of polyphenols (165.97 mg EGA/g Ex) and flavonoids (37.46 mg EQ/g Ex).
Strong antioxidant activity was indicated by DPPH IC50 of 31.04 µg/mL.
Notable antibacterial effects against Staphylococcus aureus (18 mm) and Bacillus subtilis (13 mm).
Extract significantly reduced inflammation in treated rats compared to control, similar to diclofenac treatment.
No adverse effects were observed, indicating safety in oral administration.

Alia et al. (2026) studied this question.

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