Iridium-catalyzed amidation achieves high yields in arenes, suggesting a new method for amide synthesis.
The iridium‐catalyzed C–H amidation of two classes of arenes was developed, using N ‐methoxybenzamide as the amidating agent via N─O bond cleavage to form metal‐nitrenoid intermediates. This transformation proceeds with precise site selectivity, mild conditions, and high yields, offering a practical and complementary approach to existing amide synthesis protocols.
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Hu et al. (2026) studied this question.
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