Explores alkylation of amides using terminal alkyne, suggesting a new catalytic method.
)-H bond adjacent to a nitrogen center direct alkylation of amides with terminal alkyne without an external reductant. In the presence of a cationic iridium(I) catalyst with a BiPhePhos-like ligand, this alkylation protocol allows the rapid construction of a series of corresponding alkylated products in moderate to good yields.
No takes yet. Share an insight, caveat, or question.
Song et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: