Key result
Renal biopsy diagnoses intravascular large B-cell lymphoma presenting with nephrotic syndrome and unexplained fever.
Why the study?
Intravascular large B-cell lymphoma presents with heterogeneous and nonspecific features, often leading to delayed diagnosis.
Answers are grounded in this paper and cite their sources.
Renal biopsy warrants consideration in nephrotic syndrome with unexplained fever; supports its utility for diagnosing rare intravascular large B-cell lymphoma.
Intravascular large B-cell lymphoma (IVLBCL) is a rare, aggressive subtype of extranodal diffuse large B-cell lymphoma characterized by selective proliferation of neoplastic lymphoid cells within small vessels. Its features are heterogeneous and nonspecific, often including fever of unknown origin (FUO) and organ dysfunction, leading to delayed diagnosis. We report a case of IVLBCL diagnosed by renal biopsy in a patient presenting with nephrotic syndrome and unexplained fever.
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Kanno et al. (2026) studied this question. Renal biopsy successfully diagnosed intravascular large B-cell lymphoma in a patient presenting with nephrotic syndrome and unexplained fever.
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