Recurrent switch 2 domain RAC2 mutations in intravascular large B-cell lymphoma

Figures

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  Figure 1.. Histopathology and recurrent SNVs in IVLBCL. (A) H&E-stained section of the pituitary from case no. 4, which had a RAC2 switch 2 domain mutation p. R68Q (NM 002872.5) (×20 original magnification shows large, atypical lymphocytes within sized vessels). (B) High-power H&E image showing large, atypical lymphocytes within the vascular lumen (×100 original magnification). (C) A CD20 immunostain demonstrates large intravascular B cells (×20 original magnification). (D) A CD34 immunostain confirms that large cells are confined to the vascular lumen (×60 original magnification). (E) Oncoplot24 showing top cooccurring mutations detected in 6 patients with IVLBCL. Horizontal lines represent genes, and the vertical line indicates a single patient. The type of mutations is color-coded in the legend. Mean variant allele frequency for each gene is depicted in the bar plot on the left-hand side. The tumor mutation burden (TMB) for each patient is represented on the upper side of the plot. H&E, hematoxylin and eosin.

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  Figure 2.. Distinct genetic features of IVLBCL. (A) Cooccurrence of top 10 mutations detected in IVLBCL cohort. (B) Lollipop plot showing SNVs detected in switch 2 domain of Rho GTPase family member RAC2 in 4 patients of IVLBCL. (C-D) Copy number loss of CDKN2A on chromosome 9p21 in 2 patients detected in our cohort. SNV, Single nucleotide variants.