What question did this study set out to answer?

To investigate the prevalence of intracranial aneurysms (ICAs) in patients with ADPKD and various genetic variants.

March 27, 2026Open Access

WCN26-4922 Intracranial Aneurysms Are Known to Be Common in ADPKD with PKD1 Variants, but May Also Occur in Cases with IFT140 or PKHD1 Variants

ASAkinari SekineToranomon Hospital TFTakuya FujimaruTokyo Institute of Technology TMTakayasu MoriTokyo Institute of Technology

Key Points

To investigate the prevalence of intracranial aneurysms (ICAs) in patients with ADPKD and various genetic variants.
Analyzed prevalence rates of ICAs in ADPKD patients
Evaluated association with PKD1, IFT140, and PKHD1 variants
Considered additional risk factors including family history and smoking.
ICAs were found in 9-19% of ADPKD patients
Those with PKD1 variants had a significantly higher risk
Intriguingly, ICAs may also occur in patients with IFT140 and PKHD1 variants.

Abstract

In patients with autosomal dominant polycystic kidney disease (ADPKD), intracranial aneurysms (ICAs) have been reported in 9–19% of patients, corresponding to approximately a sevenfold higher risk than in the general population. Known risk factors include a family history of subarachnoid hemorrhage or ICA, a history of smoking, and the PKD1 genotype.

AI에게 질문

Bookmark

View Full Paper

Cite This Study

Sekine et al. (Wed,) studied this question.

synapsesocial.com/papers/69c6209315a0a509bde191ac https://doi.org/https://doi.org/10.1016/j.ekir.2026.105125

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

AI에게 질문

Bookmark

View Full Paper