WCN26-4922 Intracranial Aneurysms Are Known to Be Common in ADPKD with PKD1 Variants, but May Also Occur in Cases with IFT140 or PKHD1 Variants

In patients with autosomal dominant polycystic kidney disease (ADPKD), intracranial aneurysms (ICAs) have been reported in 9–19% of patients, corresponding to approximately a sevenfold higher risk than in the general population. Known risk factors include a family history of subarachnoid hemorrhage or ICA, a history of smoking, and the PKD1 genotype.