Systematic review reveals coronary aneurysms and dissections cause coronary syndromes in polycystic kidney disease, highlighting potential genetic drivers.
Clinical disparities may suggest a different mechanism of aneurysm formation compared to the population without ADPKD. Nevertheless, lack of access to data of one patient and text of one article limited our conclusions. Coronary aneurysms and dissections represent a source of coronary syndromes and death in ADPKD. Mutation of ADPKD-related genes may predispose to coronary abnormalities, especially aneurysms. Further analysis regarding this association is necessary.
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Neves et al. (2016) studied this question.
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