Why the study?
Autosomal dominant polycystic kidney disease is rarely associated with spontaneous coronary artery dissection, leaving a significant gap in understanding their relationship.
Systematic Review (n=10)
Answers are grounded in this paper and cite their sources.
This systematic review highlights a rare clinical association between ADPKD and SCAD—predominantly affecting middle-aged women presenting with myocardial infarction—and demonstrates favorable short-term survival with predominantly conservative management.
Spontaneous coronary artery dissection (SCAD) is a spontaneous intimal tear of the coronary artery wall. A factor rarely associated with SCAD is autosomal dominant polycystic kidney disease (ADPKD). Using the PRISMA guidelines, we identified 10 unique cases of SCAD in ADPKD patients reported between 1998 and 2021. Ages ranged from 36 to 59 years, with an average of 44.6 years. The majority of patients were female (80%). Each case was diagnosed with a cardiovascular event: ST-elevation myocardial infarction (STEMI) in 40%, non-ST elevation myocardial infarction (NSTEMI) in 50%, and stable angina in 10%. Conservative management was used in 60% of cases. There is a significant gap in our understanding of the relationship between SCAD and ADPKD. Polycystin complex can lead to structural abnormalities in blood vessels, resulting in vascular leaks and vessel rupture. This suggests that ADPKD patients may have an elevated risk of arteriopathies, including coronary artery dissection.
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Milutinovic et al. (2024) conducted a systematic review in Spontaneous coronary artery dissection (SCAD) in autosomal dominant polycystic kidney disease (ADPKD) (n=10). Autosomal dominant polycystic kidney disease (ADPKD) was evaluated on Clinical presentation, management, and mortality of SCAD in ADPKD.
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