Key result
ADPKD can manifest with severe, potentially fatal coronary aneurysms and spontaneous dissections.
Why the study?
The association between coronary artery aneurysms and dissections and autosomal dominant polycystic kidney disease is rare and not well established, warranting further investigation.
Case Report (n=1)
This case highlights that autosomal dominant polycystic kidney disease can be associated with severe and potentially fatal coronary aneurysms and dissections.
BACKGROUND: Autosomal dominant polycystic kidney disease is the most common hereditary kidney disorder, characterized by the progressive formation of renal cysts due to genetic mutations. In addition to kidney involvement, autosomal dominant polycystic kidney disease is associated with various extrarenal complications, including cysts in other organs, cerebral aneurysms, and cardiac lesions. Although less common, coronary aneurysms and dissections can also occur, an association that will be explored in this study. CASE PRESENTATION: This report describes a 50-year-old, Caucasian male patient with autosomal dominant polycystic kidney disease who was previously submitted for a kidney transplant and later developed coronary aneurysms and dissections. Subsequently, the patient was submitted for myocardial revascularization and multiple attempts to restore cardiac vasculature. CONCLUSION: The patient developed hemodynamic instability and died 2 days after the final procedure. Managing such a patient is complex, and prevention and continuous monitoring are essential to guide the best surgical approach.
No takes yet. Share an insight, caveat, or question.
José Knopfholz (2025) conducted a case report in Autosomal dominant polycystic kidney disease (n=1). Autosomal dominant polycystic kidney disease was evaluated. A patient with autosomal dominant polycystic kidney disease developed severe coronary aneurysms and dissections, highlighting a rare but fatal cardiovascular complication of the disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: