What question did this study set out to answer?

To develop a high-throughput assay for evaluating AQP2 water permeability and identifying its direct inhibitors.

March 28, 2026Kidney International ReportsOpen Access

WCN26-7279 Association Between AI-Derived Retinal Aging Speed and eGFR slope in Japanese Health Checkup Participants

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Authors

YKYoichi KadohShimane University JYJun YoshinoShimane University TOTomohiro OkaShimane University

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Implication

Observational study investigates the impact of AI-derived retinal aging on kidney function in Japanese health checkup participants, suggesting a link.

Key Points

To develop a high-throughput assay for evaluating AQP2 water permeability and identifying its direct inhibitors.
Utilized mpkCCD cells to study AQP2 function.
Verified AQP2 expression through Western blot and immunofluorescence.
Conducted water transport assays using Transwell plates to measure osmotic gradients and water movement.
AQP2 was upregulated with vasopressin analog stimulation.
Phosphorylated AQP2 was localized to the apical membrane upon stimulation.
Volume changes in the apical compartment indicated water transport activity.

Cite This Study

Kadoh et al. (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e07c2 https://doi.org/10.1016/j.ekir.2026.104895

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Implication

Observational study investigates the impact of AI-derived retinal aging on kidney function in Japanese health checkup participants, suggesting a link.

WCN26-7279 Association Between AI-Derived Retinal Aging Speed and eGFR slope in Japanese Health Checkup Participants

Discussion

Member takes

Implication

Key Points

Cite This Study

WCN26-7279 Association Between AI-Derived Retinal Aging Speed and eGFR slope in Japanese Health Checkup Participants

Discussion

Member takes

Implication

Key Points

Cite This Study

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