Key result
In a rat model of early-stage heart failure, the expected increase in AQP2 and p(Ser256)-AQP2 abundance was blunted despite hyponatremia, hypo-osmolality, and increased vasopressin V2 receptor expression.
Population
68 rats with early-stage heart failure induced by coronary artery ligation (LAD) or sham operation.
Comparison
1-desamino-8-D-arginine vasopressin 0.5 ng h-1… vs Vehicle and/or standard sodium diet and/or sham…
Design
Preclinical
Follow-up
17 days after surgery
Authors
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Impaired AQP2 response in early HF rat model; hypothesis-generating for AT1A mechanisms and requires human validation.
In a rat model of early-stage heart failure, the expected AVP-induced increase in renal AQP2 is blunted despite increased V2 receptor expression, likely due to decreased AT1A receptor abundance.
Lütken et al. (2015) studied Early-stage heart failure (n=68). DDAVP and low sodium diet vs. Sham operation and vehicle was evaluated on Inner medullary AQP2 and p(Ser256)-AQP2 protein abundance. In a rat model of early-stage heart failure, the expected increase in AQP2 and p(Ser256)-AQP2 abundance was blunted despite hyponatremia, hypo-osmolality, and increased vasopressin V2 receptor expression.
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