Instructional experiment demonstrates NMR spectral assignment in organic chemistry, highlighting synthesis techniques.
Nuclear magnetic resonance spectroscopy holds a premier position as a tool for structure elucidation in organic chemistry. With the increased availability of high-field Fourier-transform spectrometers in undergraduate laboratories, there is an increased need for good instructional experiments. We describe a reliable one-step synthesis of a moderately complex structure, and a straightforward 1H NMR spectral assignment problem that illustrates the use of coupling constants for the determination of positional relationships, geminal coupling, and correlation spectroscopy (COSY) for the identification of coupled signals.
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Rusterholz et al. (1997) studied this question.
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